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Among comic book fans, this limited eight-part series is arguably the most contraversial crossover event, written by Brian Michael Bendis and illustrated by Oliver Coipel since Bendis' last contraversial universe-altering Avengers: Dissasembled.
The story prominently features two superhero teams: the New Avengers (another Bendis creation) and the X-Men (the team from the Astonishing book) who come together at the beginning of the story to deal with a specific problem: how to deal with the Scarlett Witch, a long-time Avenger who recently had a mental breakdown as outlined in the events of Dissasembled, whose reality-altering mutant powers have grown out of control.
Without wanting to give away much of the plot, I'll just say that attempting to "deal" with an unstable mutant of a nearly omnipotent power level who also happens to be the daughter of powerful Marvel villain Magneto and sister to the overprotective and morally flexible Avenger Quicksilver can lead to some unexpected, universe-altering consequences. While the House of M storyline itself is complete, it's impossible to look at at a vacuum, as it ties up several year-long stories from both the Avengers and X-Men books, and drastically alters the status quo for all mutants within the Marvelverse. I completely understand why a lot of fans have issues with this book and the influence it had on storylines up to this day, but as a fan of both high drama and the delightfully dysfunctionnal extended Magneto family, this was a real treat for me.
This book works both because of the sheer amount of detail and alternative world-building involved, and because it uses the setting to do some brilliant character exploration. Members of both superhero teams get their moments to shine, but I especially enjoyed everyyhing involving Pietro and Wanda (Quicksilver and Scarlett Witch). Bendis' specific brand of quippy, conversational dialogue is complemented by Coipel's distinctive and extremely expressive art. The latter's style takes some getting used to, but really allows the emotional moments to shine.
I'd definitely reccomend it to anyone, but you'll probably need to read some more comic titles to get the full context. I'd say Avengers:Dissasembled and the follow up Decimation are a must.