We headed to the East Coast of USA for a 3 week road trip in September 2011. I spent a huge amount of time researching where to go and who to book it with to get the best deals. Travel Republic came up trumps for 2 hotels i was desparate to stop with. I looked everywhere and couldnt get a reasonable price, then stumbled upon these guys. They by far offered the best price. I made room requests through my booking aswell and they do advise you that these are not a given, however when we got to our hotels we had the best rooms in the house, or at least the best views which is what we were after!
They dont seem to have as much on their books, compared to other agencies, however what they do have is nearly always cheaper. Bonus you can pay a deposit and the rest by instalments which is great when your on a budget! :o)