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I amr eally struggling to see how Microsoft can market this keyboard and mouse combination as a comfort set. I have owned this desktop set for a little over 6 months now and regret buying it. As I am sure many people did, I purchased this set as I wanted interacting with the computer to not put strain on my wrists, hands, fingers etc... Considering I use computers for most of the day, I am at high risk of developing Repetitive Strain Injury (RSI) and ergonomic desktops are supposed to prevent this. I find that if anything, this set will increase my chances due to how UN-comfortable it is!
The mouse is designed to fit in either hand (To boost Microsoft's profits) however, it seems that somehow they managed to make it fit poorly in both hands. If you hold it with your hight hand, a groove in the mouse housing a Forward button digs into your 4th finger. On your left hand you have to deal with the back button doing the same on that 4th finger!
The keyboard has a slight curve which is supposed to let the hands sit at a better angle. Although some may like this, I do not, I miss keys constantly as they are not where I feel they "should be". A small complain that I do have, which can actually be a real hassle is the tiny shift key - I have just measured it as being a little over 1cm in width, this means that I must get my little finger to hit it perfectly or have to put up with hitting the key which will produce "\\\\\\\\\\\\\\\\\\\" over and over again.
The lack of a sleep function for the keyboard makes batteries run out extremely fast also. Luckily I have rechargeable ones so it costs me less but it is still a cost.