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We live in a house of girls and got a Wii about a month ago. As a bit of a metal fan myself I bought Guitar Hero: warriors of rock as a bundle with a guitar and we all agree that it's one of the best games we own. I personally don't play guitar or have any real musical ability and haven't found myself at a major disadvantage to my friend who does, but I have noticed my rhythm improving and I feel like I understand the music a bit better. Even though we don't know a lot of the songs (and sometimes don't enjoy the style of music) the game is really fun nonetheless and as you learn the songs you get better at the game. The styles range from Fall Out Boy to Rammstein to Def Leppard and the songs cover over 50 years so there is something for most people and having never picked up guitar hero before, I was able to complete a song within an hour although I am by no means an expert yet. The different levels are really great as it means you can play straight away but won't get bored because as soon as you've mastered easy, there's practically a whole new game waiting for you on the next level up.
As you play more and improve, you unlock more things to customize gameplay such as venues, guitars and outfits for your 'rocker' and there are even some unlockable songs. I'm working my way through the quest mode and it's great because it encourages you to do well in all songs, not just the ones you like. This part of the game can be addictive! The storyline in quest mode is a bit cheesy and, at points, just plain weird, but it's all satire and meant to be laughed at.
The game increases hand-eye coordination and gives you a better sense of rhythm, but it does get frustrating at times when you just can't get the beat of a song. There is a function to connect the game to a Nintendo DS, but as I do not own one of these I cannot comment on how good it is, but that's something to try out another time!