The story.
House (the name of the show) is actually a man, Hugh Laurie in fact, and he is the star of the show.
Based in a hospital, the programme is about a man who is by far one of the greatest medical minds currently living on the planet. He leads a team of very talented doctors in a department that focuses on theoretical medicines and treatments. When I say theory what I mean is they are given many cases of people with strange illnesses, that no other doctors can give answers for and then they break the symptons down and try to figure out what is causing the problems.

Leading them to figure out a way to treat and eventually cure!

House is a man with a past, a painfull past (literally he had an operation that left him disabled and in pain every day from that point). Because of this pain he is very edgy with people, messes with their minds and lives and pushes any one close to him away. Although this sounds a bit boring, he actually manages to make what he does very entertaining and often vcery funny.
The group of doctors working under him are very different people with very different lives, but somehow come together well when needed for making break throughs.
House also has a deep love for the woman that runs the hospital but because of his nature all he ever does is push her away and make her miserable, which couldn't be further away from what he really wants.

My opinion.
I only began watching this show after it had already run for three series but as soon as I had seen a few episodes I was hooked and immediately caught up with all the episodes I had missed.
I am a fan of Hugh Laurie and find that he particularly excels whilst playing house. You get drawn in to the whole medical world but it is done in such a way that you don't get lose with the terminology like many other medical dramas do, instead you find yourself interested by what they're saying and wanting to find out more.

Throw the gripping medical science and strange illnesses in with the brilliant humour and great story lines and what we get is an amazing tv series.
There is a seperate story picked up in every episode but we also have deep underlying stories running constantly, but not just with the main character, there are stories running for each individual character with substantial screen time. This is one of the things that I like most.

If you were to pick a medical drama to follow, above any other, I would certainly recommend giving this one a go. It has more than just staff getting it on with each other and family feuds!

Give it a go!

Enjoy.